Nowadays, the quality of life is improving, the pressure of urban life is increasing, and the irregular diet has caused many people to suffer from gastrointestinal diseases. Rectal cancer is one of the major gastrointestinal diseases that threaten human health at present, and it is difficult to be detected because of its inconspicuous aura and symptoms. Chemotherapy is one of the important methods to treat rectal cancer. On the one hand, chemotherapy drugs kill tumor cells; on the other hand, they have certain harmful effects on normal cells of human body and suppress the immune function of the body. Therefore, in the process of chemotherapy, scientific care is the key to ensure the smooth implementation of chemotherapy. In order to make rectal cancer patients receive treatment smoothly, the experience of chemotherapy nursing for intestinal cancer is discussed as follows. Pre-chemotherapy care Before chemotherapy, two main aspects of care should be done: 1. Patient psychological care: If patients lack sufficient knowledge about chemotherapy, have concerns, feel worried, nervous or even afraid, and lack confidence to overcome the disease, it is very unfavorable to chemotherapy. Therefore, the patient’s psychological state should be understood in a timely manner, patiently and meticulously explain, so that the patient has a certain understanding of the role of chemotherapy drugs and side effects, to relieve their ideological concerns, so that they actively cooperate with the treatment and improve the patient’s confidence in chemotherapy. 2.Preparation work before chemotherapy. Before chemotherapy, various auxiliary examinations should be done, such as blood routine, liver function, kidney function, electrocardiogram, etc. Before chemotherapy, we should strengthen nutrition and enhance physical fitness, such as diet therapy and other supportive treatments.