Impaired megakaryocyte maturation is often considered a typical change in the bone marrow examination of idiopathic thrombocytopenic purpura (ITP). In clinical work, it is found that diseases such as connective tissue disease, hypersplenism, and megaloblastic anemia can also manifest as peripheral thrombocytopenia and impaired bone marrow megakaryocyte maturation. The main causes of bone marrow megakaryocyte maturation disorders are hypersplenism, macrophage leukemia, myeloproliferative disease, idiopathic thrombocytopenia, and the general view that megakaryocyte maturation disorders mainly manifest as normal or increased number of bone marrow megakaryocytes and reduced platelet-producing megakaryocytes, which can cause thrombocytopenia. It is a characteristic change in the bone marrow picture of idiopathic thrombocytopenic purpura (ITP), but clinically it is found that megakaryocyte maturation disorder also exists in some other diseases. It is important to go to the hospital for a formal examination and then to treat the disease accordingly. Megakaryocyte maturation disorder is not a diagnosis of a disease, but a clinical symptom or phenomenon that requires treatment for the primary cause. For example, splenectomy, hormone therapy, symptomatic support therapy, immunosuppressive therapy. You should take rest, avoid overexertion and trauma in your life. Exercise appropriately according to physical strength, and pay attention to avoid allergy-causing drugs or foods. Regulate emotions and avoid mood swings or mental stimulation.