Tramadol, or Tramadol Hydrochloride, is generally recommended not to be used with Tramadol Hydrochloride and Diclofenac Sodium to avoid synergistic analgesic effects and more serious adverse reactions. Tramadol hydrochloride is a non-opioid drug with central analgesic effects. It is used for acute pain, chronic pain, mild to moderate cancer pain, fracture or all kinds of postoperative pain, neuralgia, sudden cardiac pain, arthralgia, labor pain relief. Adverse reactions such as nausea, vomiting, abdominal pain, dizziness, headache, and drug dependence can be seen with Tramadol hydrochloride. The drug is contraindicated in people who are allergic to Tramadol, children under 12 years of age, severe respiratory depression or brain damage, gastrointestinal obstruction. Diclofenac sodium belongs to a non-steroidal anti-inflammatory analgesic used for acute mild and moderate pain, fever, etc.. Adverse reactions such as acid reflux, burning sensation, nausea, poor appetite and other adverse reactions are seen. The drug is contraindicated for people who are allergic to the product and others. Although the current instructions for Tramadol Hydrochloride and Diclofenac Sodium do not indicate whether the two drugs can be used together, it is generally recommended that Tramadol Hydrochloride and Diclofenac Sodium be used together to avoid synergistic analgesic effects and more serious adverse reactions such as nausea and vomiting. It is therefore recommended that the two should not be used together to avoid adverse effects. At the same time, the above two drugs must be used rationally under the guidance of a doctor, not for private use.