Endogenous creatinine clearance can reflect renal function, and the reference value of endogenous creatinine clearance is between 80 and 120 ml/min. If the endogenous creatinine clearance has decreased, it may be related to drug reasons, primary kidney disease, secondary kidney disease and so on.
1. Drug causes: drugs that commonly affect endogenous creatinine clearance, including cimetidine and mebendazole, can also show a decrease in endogenous creatinine clearance.
2. Primary renal disease: commonly found in patients with chronic glomerulonephritis, which may be due to the damage of glomerular function glomeruli, the filtration rate of glomeruli decreases, and the decrease of endogenous creatinine clearance will also occur.
3. Secondary kidney disease: such as diabetic nephropathy, hypertensive nephropathy, etc., due to impaired renal function, which affects the glomerular filtration rate, all of which will lead to decreased endogenous creatinine clearance.
There are many reasons for low endogenous creatinine clearance, so we suggest patients to improve the relevant examinations to clarify the causes and actively cooperate with doctors to standardize the treatment.