Symptoms of dry syndrome: 1.Primary patients mostly have dry mouth and eyes as early symptoms. 2.Secondary patients have light local symptoms, and systemic symptoms are mostly accompanied by their coexisting autoimmune diseases. 3.Local symptoms include dry mouth, little saliva, dental caries, dry, cracked tongue, atrophy of tongue papillae, oral ulcers, dry eyes, foreign body sensation, and no tears when crying in severe cases. There is often unilateral or bilateral enlargement of the parotid and submandibular glands;. Dry, itchy and flaky skin, dry and itchy vagina, difficulty and burning pain during sexual intercourse; dry nasopharynx or chronic cough. 4. Systemic symptoms include joint pain, myalgia, rash, erythema nodosum, and purpura. The nervous system may show psychoneurological symptoms, epileptic-like seizures, hemiplegic hemianopia, ataxia, etc.; renal lesions are highlighted by renal tubular acidosis and renal uremia, and hypokalemic paralysis may occur; due to dryness of the pharynx and esophagus, it may cause dysphagia, gastroscopy with atrophic gastritis, hepatosplenomegaly and elevated serum glutamate transaminase are not uncommon, and occasionally chronic pancreatitis; lymphoid tissue hyperplasia is generally benign and may The incidence of malignant lymphoma is significantly higher. Laboratory tests 1. Orthocytic anemia, leukopenia and mild eosinophilia are common in a few patients, and hematocrit is increased in 90% of patients. Half of the patients have hypergammaglobulinemia, and all immunoglobulins are increased, mainly IgG. A variety of autoantibodies can be detected in the serum, including rheumatoid factor, antinuclear antibody, anti-SS-A antibody, anti-SS-B antibody, and anti-RNP antibody, but anti-SS-A and anti-SS-B antibodies are the most important. Saliva levels of IgM and IgG are increased, and salivary b2 microglobulin concentrations are higher than in serum. Complement levels are generally normal, and can be significantly lower in combined vasculitis. Diagnostic and classification criteria 1.Have dry eyes for more than 3 months; recurrent ocular gritty sensation; using tear substitutes more than 3 times a day. 2.Have dry mouth for more than 3 months; recurrent and persistent salivary gland enlargement; swallowing dry food requires frequent drinking of liquid. 3.Filter paper test 5mm/5 points. 4.Foci of mononuclear cell infiltration in the lower lip mucosa biopsy. 5, Parotid imaging: salivary gland isotope scan; saliva flow rate. 6, Positive serum anti-SS-A and anti-SS-B antibodies. The diagnosis of primary dry syndrome is confirmed if at least 4 of the above 6 items are present and another connective tissue disease, lymphoma, AIDS, nodular disease, graft-versus-host disease is excluded. If there is a definite connective tissue disease with 1 or 2 of the above items and two of 3, 4 and 6 positive at the same time, it can be used as the diagnostic criteria of secondary dry syndrome.