The plague virus is extremely dangerous due to its highly contagious and rapidly progressing condition, and the disease can seriously jeopardize the lives of patients. Bubonic plague is a virulent infectious disease caused by Yersinia pestis infection, which can be transmitted through the bite of rat fleas, human-to-human droplet transmission, as well as direct contact, and is highly contagious. Plague, also known as the Black Death, the onset of acute, patients infected with the virus can be manifested as chills, high fever, severe headache, vomiting, shortness of breath, tachycardia and other uncomfortable symptoms, severe cases can be seen in the early drop in blood pressure, fuzzy consciousness, delirium, and other symptoms, and even pleural effusion, respiratory failure, shock, cardiac failure, and other complications, a serious risk to the patient’s life. Plague virus infection should be timely and strict isolation and disinfection of patients, and follow the doctor’s instructions for emergency treatment, in order to avoid the spread of the disease, triggering adverse consequences.