The most recent domestic guideline for hepatitis B is the 2019 Guidelines for the Prevention and Treatment of Chronic Hepatitis B Virus. It was jointly developed by the Chinese Medical Association’s Hepatology Section Chinese Medical Association’s Infectious Diseases Section. Chronic hepatitis B is one of the common chronic infectious diseases in China, which seriously endangers people’s health. To further standardize the prevention, diagnosis and treatment of chronic hepatitis B, the Hepatology Branch of the Chinese Medical Association and the Infectious Diseases Branch of the Chinese Medical Association organized relevant domestic experts to develop this Guideline based on the latest research results at home and abroad and in accordance with the principles of evidence-based medicine, as a standardized guide and reference for the diagnosis and treatment of hepatitis B.