A Y chromosome deletion usually refers to the loss of a segment of the Y chromosome. The presence of a Y chromosome deletion can be determined by a blood test for males and amniocentesis for fetuses. Deletions can occur at any location on any chromosome, and can be categorized as terminal or intermediate, depending on the location of the missing segment.Y chromosome microdeletions are one of the leading causes of male infertility, which usually occurs in men with Y chromosome microdeletions. When Y chromosome deletion occurs, in order to reproduce the next generation, it is recommended to do in vitro fertilization (IVF), which requires the selection of chromosomally normal sperm for IVF, which can avoid the chromosomally defective sperm from causing Y chromosome deletion in the next generation. After conception, amniocentesis is recommended during pregnancy for genetic screening to alert for the presence of Y chromosome deletion. If the patient has a Y chromosome defect, it is recommended to consult a doctor in time, under the guidance of the doctor, complete the relevant examinations to clarify the cause of the disease and take the correct treatment measures.