People with uncontrolled epilepsy, severe allergic reactions to previous vaccinations, pregnant women, and people with fever are not suitable for the third vaccination. In the current stage of epidemic prevention and control, the “third shot” often represents the booster shot of the Xinguan vaccine or the third shot of the recombinant subunit vaccine, i.e., by increasing the number of vaccination shots, the neutralizing antibodies, which have been gradually decreasing, can be increased rapidly, thus producing a better protective effect. However, people with the following diseases should not be vaccinated or defer vaccination. 1. People with uncontrolled epilepsy and other serious neurological diseases such as transverse myelitis, Guillain-Barre syndrome, demyelinating diseases, etc. 2. Those who have had severe allergic reactions to previous vaccinations, such as acute allergic reactions, angioneurotic edema, respiratory distress, etc. 3. Those who are allergic to vaccine components and excipients and substances used in the preparation process. Inactivated new coronavirus vaccine excipients mainly include: disodium hydrogen phosphate, sodium chloride, sodium dihydrogen phosphate, aluminum hydroxide. 4. Persons who are experiencing fever, or suffering from acute illness, or acute exacerbation of chronic disease, or patients with uncontrolled severe chronic disease. 5. Women during pregnancy. For the sake of personal health, when you have the above conditions, you need to carefully consider vaccination, and if necessary, consult your doctor.