Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is an inherited metabolic defect that is inherited as an X-complex dominant trait and is more prevalent in males than females. Due to the many variants of G6PD deficiency, the clinical manifestations vary greatly from mild cases with no symptoms to heavy cases with congenital non-spherocytic hemolytic anemia, which is usually induced by the use of certain drugs, fava beans or acute hemolysis after infection, and can be life-threatening in severe cases. Some cases develop after eating fava beans, so it is commonly known as fava bean disease.
About 200 million people worldwide suffer from this disease. China is one of the high incidence of the disease, is characterized by the distribution of high in the south and low in the north, the prevalence rate of 0.2-44.8%. Mainly distributed in the provinces south of the Yangtze River, Hainan, Guangdong, Guangxi, Yunnan, Guizhou, Sichuan and other provinces for high. We Jieyang is also a high prevalence area.
How to prevent G-6-PD deficiency?
1. prohibit the consumption of fava beans or fava beans raw processed products.
2. Prohibit the use of naphthalene-containing stink pills into the closet to repel insects.
3. Avoid infectious triggers, such as viral hepatitis, influenza, pneumonia, typhoid, mumps, etc.
4. Drugs to avoid: drugs that cause hemolysis in patients with G-6-PD deficiency mainly include antimalarials (primaquine, paromalarial quinoline, pentaquine, etc.), sulfonamides (sulfamethoxazole, sulfapyridine, p-aminobenzenesulfonamide, sulfacetamide, etc.), antipyretics and analgesics (acetanilide, aminopyrine, pautazone, etc.), furans (furantin, furazolidone, furacilin, etc.), others (thiazole sulfone (nalidixic acid, nilidazole, trinitrotoluene, naphthalene (camphor), methylene blue, Chuan Lian, toluidine blue, etc.). Chinese medicine: peppermint, camphor, naphthol, Chuan Lian, oxalis powder, waxflower, bear bile, pearl powder, honeysuckle, oxalis, opening tea, seven cents, infantin, oxalis antidote pill, infant protection dan.
Whenever symptoms such as fever, abdominal pain, vomiting, yellow or pale face, yellow-brown or dark red urine appear after infection or contact or consumption with the above foods or drugs for several hours or days, it is an acute hemolytic reaction and it is advisable to seek urgent medical attention!