Mixed ground glass nodules with vacuolar sign generally refers to the pathologic description of both lungs by imaging, which may be related to emphysema, pulmonary pemphigoid, bronchopulmonary carcinoma and other diseases. 1. Emphysema: also known as obstructive emphysema, is a chronic disease, manifested as exertional shortness of breath, progressive dyspnea, chest tightness and other symptoms, is an irreversible disease, the imaging examination can be seen mixed ground glass nodules with vacuolar sign. 2. Pulmonary herpes: the formation of air-containing cystic cavities with a diameter of more than 1 cm in the lungs, the symptoms are related to the number and size of the herpes and whether there are other lung diseases, and vacuolar signs can be seen in mixed ground-glass nodules in the imaging examination. 3. Bronchopulmonary cancer: the cause of the disease is still unknown, and it is related to smoking, radiation, heredity and other risk factors, manifesting as cough, sputum, blood in sputum, chest pain and other symptoms, and the sign of vacuoles can be seen in the imaging examination of mixed ground-glass nodules. Mixed ground glass nodules with vacuolar signs need to go to the hospital in time, under the guidance of medical advice for standardized treatment.