There are mainly the following reasons for the decrease in progesterone after taking drospirenone tablets: First, there is a process of absorption and metabolism in the body after taking drospirenone tablets, and it is impossible to make the progesterone level in the body rise immediately. Second, after a small number of women take drospirenone tablets, the body is not sensitive to the reaction of the drug, which may also lead to a decrease in progesterone instead of an increase. Third, when suffering from certain diseases, such as primary hypertension and congenital adrenal hyperplasia, the body’s consumption of progesterone increases, and a decrease in progesterone levels may also occur. Didroxyprogesterone tablets are a kind of progestin and need to be taken according to the course of treatment under the guidance of a doctor, which can improve the progesterone level in the body. It can be taken when a woman suffers from progesterone deficiency leading to menstrual disorders and pre-miscarriage due to lower progesterone in early pregnancy.