Palmoplantar pustulosis is a chronic recurrent disease, this disease is characterized by the periodic occurrence of deep in the erythema on the basis of small aseptic pustules, accompanied by keratinization, desquamation, preferably in the palmoplantar area, the etiology of this disease is unknown, some scholars suspect that it is related to the infection foci, it is considered to be pustular bacterial rashes; some scholars believe that it is a confined pustular psoriasis, the treatment of this disease is very tricky in the clinic. Song Qunxian, Department of Dermatology, The First Affiliated Hospital of Henan College of Traditional Chinese Medicine I used a combination of traditional Chinese and Western medicine to treat 30 cases of palmoplantar pustulosis, and achieved more satisfactory results, which are now reported as follows: Clinical data: of the 30 patients, 14 were male and 16 were female; the youngest was 21 years old, the oldest was 53 years old, and the average age was 37 years old; the duration of the disease was the shortest for 1 month, and the longest for 10 years. Treatment: Chinese herbal medicine to clear away heat and detoxification, cool the blood and promote dampness, water decoction, one dose per day, morning and evening, twice, Chinese herbal formula composition: Scutellaria baicalensis 10g Gardenia gardenia 10g Radix et Rhizoma Ginseng 10g Radix et Rhizoma Dioscoreae 20g Cyperus rotundus 10g Huang Lian 10g Poria Cocos 10g Poria cocos 10g Polyporus pigmentus 10g Atractylodes macrocephala 10g Mangosteen 20g Botrytis cuspidatae 20g Radix glycyrrhiza glabra 10g Mudanjiang peony bark 15g Rhizoma Gromwelliae 15g Chinese herbal external wash to clear away heat and detoxify the toxin and remove dampness. The main agent for relieving itching is decoction of water for external washing, one dose per day, the formula is as follows: 20g of bitter ginseng, 30g of cypress, 30g of amaranth, 30g of moss, 30g of dandelion, 30g of umeboshi, 15g of the above herbs will be decocted into 500mL of warm soak the hands and feet for 20 minutes per night, and then applying ointment externally, which is divided into Group A and B. Group A is coated with Ao Neng Cream (loxacortisone cream) at night to seal the bag, and Huang Lian Ointment (the preparation of our hospital) during the day. Group B: apply Eloxon (mometasone furoate cream) in the evening to seal the package, apply skin net (our hospital preparation) in the daytime, use the medicine for one week, then change to group A, alternately, the course of treatment is 7-9 weeks. Criteria for determining the efficacy of the treatment: according to the “Clinical Disease Diagnosis Cure and Improvement Criteria”: Cured: no new erythema, pustules, all lesions subside, itching, pain disappears. Improvement: there are still a small amount of new erythema, pustules, lesions partially subside, does not affect daily life, work. Ineffective: there are a lot of new erythema, pustules, lesions subside less than 50% of the area, itching, pain obviously affect daily life and work. Treatment results: 30 patients were cured in 12 cases, improved in 15 cases, ineffective in 3 cases, ineffective in 3 cases, symptoms were relieved after oral intake of Avitamin A. The total effective rate was 90%. Discussion: 1. Palmoplantar pustulosis is a kind of chronic recurrent disease, preferred in palmoplantar, on the basis of erythema, periodic occurrence of deep in the aseptic small pustules, accompanied by keratinization, desquamation, the etiology and pathogenesis so far have not been completely understood, some scholars suspect that it is related to the foci of infection, it is considered to be pustular bacterial rashes; some people believe that the disease is allergic to mercury, copper, tin and other metal elements, which are absorbed mainly through the ingestion of metal-containing foods or use of metal dental materials. These elements are mainly absorbed into the blood circulation through eating metal-containing food or using metal dental materials, and then excreted through sweat to the thicker keratin layer of the palm and plantar sensitization and the onset of the disease, most scholars believe that it is a limited pustular psoriasis. Our department has found several cases of pustular psoriasis of palmoplantar origin, which later developed into psoriasis. 2. At present, there are many treatment methods for this disease, such as glucocorticoid, polyaromatic retinoic acid, traditional Chinese medicine, UVB treatment, etc., but the therapeutic effect is not satisfactory. 3. The author believes that the use of Chinese and Western medicine combined treatment of this disease is better than the use of Chinese medicine or Western medicine alone. Chinese medicine believes that this disease is related to poisonous heat and external sensation, golden stone poison attack, dampness and heat of spleen meridian, the treatment is based on clearing heat and removing toxins, cooling blood and promoting dampness. I use the method of clearing heat and detoxification, cooling blood and promoting dampness to treat this disease, the therapeutic effect is satisfactory, in the formula of scutellaria baicalensis, gardenia, cyperus rotundus, Huang Huanglian clearing heat and detoxification, raw land, moutan skin, white fescue to cool blood, poria, poria, bitter ginseng, cangzhu, mossy skin, the ground skin to strengthen the spleen to remove the dampness, drying the dampness to stop the itch, altogether put together to clear the heat and detoxification, cool blood to remove dampness and stop the itch of the function, together with the bitter ginseng, cyperus rotundus, marmalade, mossy skin, dandelion, ume externally washed to make the drug Directly to the place of disease, at the same time increase the local skin hydration, is conducive to the full absorption of topical drugs, (two hormone ointment and non-hormone ointment alternate application, to prevent the occurrence of hormone side effects and drug resistance, but also improve the efficacy of the drug to reduce recurrence) Ao Neng and Eloxon for the hormone drugs, with anti-inflammatory, inhibit local inflammatory response, Huanglian cream and skin net for our hospital preparations, has a Yellow fever cream and skin net are our own preparations, which have the effect of clearing heat and detoxifying the toxin.