ECG t-wave inversion is a condition in which the ECG t-wave is below the equipotential line or is in the opposite direction to the main wave. This condition can be seen in organic heart disease, or it can be a functional cause. 1. Organic heart disease: ECG t-wave inversion is commonly seen in coronary atherosclerotic heart disease, myocardial ischemia, myocardial strain, myocardial infarction, etc. In addition, there are also myocarditis, pericarditis, hypertrophic cardiomyopathy, congenital heart disease, hypertension, left ventricular strain, and so on, which can all cause ECG t-wave inversion. It is necessary to determine the diagnosis through detailed examination, such as cardiac ultrasound, myocardial enzyme profile, coronary angiography, etc. For patients with coronary artery disease and myocardial ischemia, antiplatelet drugs such as aspirin, statins such as atorvastatin calcium tablets, coronary vasodilating drugs such as nitrates, etc., and interventional therapy or surgical intervention, if necessary. For myocarditis patients need to use nutritive myocardial drugs, coenzyme Q10 and so on. 2. Functional reasons: some normal people ECG t-wave inversion, without any symptoms, no medical history, check other items without abnormalities, this situation generally belongs to the functional reasons, do not have to deal with. There are also some cardiac neurosis, menopausal women, may appear ECG t-wave inversion. Therefore, for ECG t-wave inversion, it is necessary to combine the medical history, symptoms and relevant auxiliary examinations to determine the diagnosis, and medication should be administered under the guidance of a doctor.