Liver depression and spleen deficiency should be treated through general measures, medication and physical therapy. General measures: patients need to regulate work and rest, ensure sufficient rest time, avoid staying up late for a long time, and pay attention to warmth, exercise and keep a happy mood. Diet needs to be regular, eat less spicy stimulation, greasy, cold food, avoid drinking alcohol, drinking a lot of coffee and so on. Medications: Patients can use Chinese medicines such as Atractylodes macrocephala, Poria, Coix lacryma, Chinese yam, Chaihu, Qingpi, Muxiang, Buddha’s hand, etc., or Chinese patent medicines to strengthen the spleen and benefit the qi, and ease the liver to relieve depression, in accordance with the medical advice. The adverse effects and contraindications of the above drugs are not clear. Physical therapy: Physical therapy measures such as acupuncture, cupping, gua sha and tuina can also be used to regulate the body. Patients with liver depression and spleen deficiency are advised to go to the hospital, cooperate with the doctor for active treatment, strengthen daily life management and follow up on schedule.