Hand numbness may be caused by localized pressure, physiological numbness, but also trauma, diabetic peripheral neuropathy, carpal tunnel syndrome, arthritis, cervical spondylosis and other causes. 1. Physiological numbness: sleeping on the side of the upper extremity compression of blood vessels leading to insufficient blood supply to the hands, or lack of warmth in the hands leading to local vasoconstriction and other factors may cause numbness of the hands. Generally change the position or keep warm after relief. 2. Trauma: hand epidermis by abrasions, burns, frostbite, etc. or impact, extrusion, etc., resulting in hand bone fracture, local vascular nerve injury, etc., will appear hand swelling and numbness symptoms. 3. Diabetic peripheral neuropathy: long-term poor glycemic control, may be due to microangiopathy, oxidative stress injury and other factors leading to peripheral neuropathy, involving the radial nerve of the upper limb, ulnar nerve, median nerve and so on, resulting in the innervation of the hand sensory abnormality, the emergence of hand swelling and numbness symptoms. 4. Carpal tunnel syndrome: exogenous compression of the carpal tunnel, inflammatory exudation in the carpal tunnel, resulting in local narrowing and other factors leading to pressure on the median nerve in the carpal tunnel, nerve dysfunction, and thus hand swelling and numbness. 5. Arthritis: the wrist joint, hand bone because of autoimmune, hyperuricemia, infection and other reasons for inflammatory lesions, resulting in wrist movement disorders and hand swelling and numbness. 6. Cervical spondylosis: the cervical nerve root is compressed by hyperplastic cervical vertebrae or herniated intervertebral discs, leading to distal hand swelling and numbness. Hand numbness may also be related to a variety of factors, if you exclude physiological numbness, it is recommended to consult a doctor in a timely manner, improve the examination to clarify the diagnosis, and follow the doctor’s instructions for targeted treatment to avoid delays in the condition.