Schistosomal liver disease has the potential to change transaminases. Schistosomal liver disease is a liver disease caused by a parasitic infection. Schistosomal liver disease can cause functional damage to the liver, which can lead to an increase in aminotransferases, so it is possible to change aminotransferases with schistosomal liver disease. Schistosoma can parasitize the human portal vein system, and the eggs in particular can cause significant liver damage. Eggs of schistosomes are deposited in the portal venous system and form granulomas, followed by proliferation of liver fibrous tissue, which eventually leads to parasitic cirrhosis, which in turn can be complicated by complications such as fundic esophageal varices and splenomegaly. Schistosomal liver disease may cause fever, enlarged liver size, abdominal pain, diarrhea, pus and blood stools, impaired liver function, and in severe cases, complications such as enlarged spleen, indigestion, and malnutrition. The body infected with schistosomiasis liver disease, should go to the hospital as soon as possible for examination and diagnosis, usually need to choose to use the anti-parasite drugs, the emergence of aminotransferase changes, which is also known as liver function damage, but also need to cooperate with the liver protection drugs for treatment.