When choosing drugs for brain atrophy, you can usually choose cholinesterase inhibitors or drugs to improve brain circulation. 1. Cholinesterase inhibitors: Cholinesterase inhibitors often include donepezil or galantamine, etc., which can inhibit cholinesterase, thus helping to improve the symptoms of nerve cell atrophy or damage, and can improve nerve conduction function, thus improving the symptoms of cognitive impairment caused by brain atrophy. 2. Improvement of cerebral circulation drugs: Some of the cerebral atrophy is related to vascular factors, so the symptomatic treatment can be given to improve the circulation drugs, such as ginkgo biloba extract, nimodipine, etc., which can help regulate the circulation of the brain and slow down the process of atrophy. After the appearance of brain atrophy, it is recommended to go to the hospital, to clarify the cause of atrophy, under the guidance of the doctor to choose the appropriate drug treatment, do not blindly self-medication.