Local pain symptoms aggravated after playing closed injection, commonly due to irrational selection of indications, closed drug configuration is unreasonable and other reasons, as follows: First, irrational selection of indications: such as acute injury, in the injury site directly playing closed drug, will make the injury further aggravation, resulting in pain symptoms are not relieved, or even more serious, affecting the repair of damaged tissues. Second, the closed drug configuration is unreasonable: closed drug usually contains hormones and local anesthetic drugs, if the local anesthetic drug is used too little, the patient in the injection not only will not relieve the pain, but also make the pain symptoms worsen, mainly due to the local stimulation produced by the closed drug. Therefore, the rational use of closed drug injection, can make the pain symptoms, while the injection indications and drug ratio is not reasonable will aggravate the pain.