There is no authoritative information on the ability to lie on one’s side after implantation of an infusion port. It is generally not recommended to lie on the affected side, but to lie on the healthy side. Implantable infusion ports are implantable intravenous drug delivery devices that are placed in the subcutaneous tissue of the body. There is no authoritative information on whether or not it is possible to lie on one’s side after implantation of an infusion port. Generally, patients are not recommended to lie on the side where the port is implanted, mainly to avoid localized pressure, catheter displacement, blockage, port reversal, etc. However, patients are usually allowed to lie on the healthy side. However, patients are usually allowed to lie on the healthy side, i.e., the side without the port. For patients with infusion port, they need to avoid strenuous exercise involving the upper limbs such as weight lifting and boxing during the application process, and keep wearing loose clothing to avoid pressure. At the same time, it is necessary to quit smoking and drinking, avoiding late-night labor, and maintaining a relaxed mood. In summary, implantation of infusion port needs to strengthen the daily life management as well as the care of infusion port to avoid adverse effects, patients need to go to the hospital on time for follow-up, cooperate with doctors to actively treat.