According to the norepinephrine instruction manual, the contraindications of norepinephrine: it is forbidden to combine with halogen-containing anesthetics and other catecholamines, cocaine intoxication and tachycardia patients. Norepinephrine is a strong alpha agonist, which can lead to skin mucosa, renal vasoconstriction, help to improve the symptoms of shock, suitable for acute myocardial infarction and blood volume insufficiency triggered by shock resuscitation. In addition to the above contraindications, the use of the following matters need to be noted: allergic to the drug components are not suitable for use; pregnant women in the use of norepinephrine may induce uterine vasoconstriction, blood flow is reduced, resulting in fetal hypoxia, so it is not recommended to use. In addition to this norepinephrine may also cause skin rashes, tissue necrosis, induce tissue hypoxia and acidosis and other adverse reactions. Norepinephrine must be used strictly under the guidance of a doctor, and should not be used without authorization, so as to avoid improper use of medication to induce damage to the organism.