Spitting mucus in the advanced stage of pancreatic cancer may be due to excessive secretion caused by the stimulation of tumor. It can be treated by medication and surgery. 1. Drug treatment: patients with advanced pancreatic cancer vomiting mucus can take some drugs to promote gastric power, such as domperidone, mosapride, trimethoprim and other drugs for treatment. 2. Surgery: If patients with advanced cardia cancer vomiting mucus can tolerate surgery, palliative surgery is feasible, which can help relieve the symptoms. Esophageal dilatation or esophageal stenting can also be used to solve the symptoms of esophageal obstruction and relieve the symptoms of mucus vomiting. Patients with advanced cardia cancer vomiting mucus need to go to the hospital as soon as possible to confirm the diagnosis and carry out standardized treatment under the guidance of doctor’s instruction. During the treatment period, they should take a light diet, avoid spicy and stimulating food, quit drinking and smoking, and pay attention to rest.