Neuroblastoma has an insidious onset, and once discovered have shown distant metastasis early generally no specific symptoms, no obvious pre-signs. However, according to China’s early screening program for neuroblastoma, early screening for neuroblastoma is recommended for infants with the following symptoms: Infants up to 1 year of age who have skin nodules, lumps or persistent diarrhea found on the chest or abdomen. Early screening for neuroblastoma is recommended for infants 1 to 5 years of age who have 1 of the following: unilateral protrusion of the eye, unexplained urinary retention, unexplained back pain, persistent abdominal pain that is unexplained, bone pain, limb pain, urinary incontinence, or weakness of the lower extremities. Tumor metastasis may be considered in infants and children aged 1 to 5 years if they have one or more of the following: rapid heart rate and high blood pressure; irritability and pallor; uncontrolled infection; bruising that is unexplained; widespread lymph node enlargement; and fever that is unexplained. In practice, children with these conditions should be referred to a doctor for a urine test, abdominal ultrasound, etc. If the results are positive, further investigations should be carried out to confirm the diagnosis and the next step in the treatment.