In fact, with the emergence of new drugs, the adverse reactions of chemotherapy have been significantly improved, and the pain of chemotherapy has been significantly reduced and effectively controlled. The common adverse reactions of chemotherapy for gastrointestinal tumors are introduced as follows: 1. Nausea and vomiting. The most common adverse reaction of chemotherapy is gastrointestinal reaction. Patients will have different clinical manifestations such as nausea, vomiting, constipation, diarrhea and abdominal pain. 2, bone marrow suppression. It is also a common adverse reaction, in which leukopenia is the most common, followed by thrombocytopenia, and anemia does not usually occur. 3, liver function and kidney function impairment manifestations. 4, hair loss is a low incidence of chemotherapy adverse reactions. However, it can often be regenerated. 5, local adverse reactions of chemotherapy. Such as phlebitis and local tissue necrosis caused by local chemotherapy drug penetration. 6, there are some other chemotherapy reactions. Such as cardiotoxicity, bladder toxicity, pulmonary toxicity, etc., but for for postoperative adjuvant chemotherapy for intestinal tumors is less likely to occur. Nausea and vomiting reactions are painful, and some patients even give up chemotherapy because they cannot tolerate nausea and vomiting reactions. The main reasons for nausea and vomiting are: 1. Fear or anxiety about chemotherapy before chemotherapy, so the mental guidance before chemotherapy is also important. 2, direct stimulation of chemotherapy drugs for the gastrointestinal tract. 3, drugs through direct or indirect action on the brain vomiting center to induce nausea, vomiting. The main types are: 1, acute vomiting, mainly occurs within 24 hours of chemotherapy vomiting. 2. Delayed vomiting, which mainly occurs within 1 week of chemotherapy. There are now very effective drugs for vomiting, such as: hormones, gastrofacial, numerous pentraxin blockers, etc. Diarrhea should also be given enough attention, according to the specific situation to give pretreatment, such as anti-diarrhea, rehydration, etc. Chemotherapy patients should avoid eating cold food, less greasy food, it is appropriate to eat high calorie, high protein, high vitamin, low fat, easy to digest food. Bone marrow suppression, generally speaking, chemotherapy will cause varying degrees of bone marrow suppression, the patient’s subjective symptoms are not obvious, generally often occurring white blood cell decline, for the decline of obvious patients, in addition to giving white-raising drugs, but also need to give measures to prevent infection, such as isolation, anti-infection treatment, followed by platelet decline, can be given with platelet-raising drugs, but because of the slow rise in platelets, for severe platelet Decline can be given platelet transfusion, chemotherapy rarely causes anemia, anemia can be given blood transfusion treatment, ordinary dose of chemotherapy generally does not cause serious bone marrow suppression. Liver function and kidney function damage, the vast majority of chemotherapy drugs are metabolized by the liver or through the blood circulation through the liver and kidneys, so liver injury is common clinically, liver injury is an acute process, commonly increased transaminases or increased serum bilirubin, and large doses of chemotherapy drugs can cause liver fibrosis, so chemotherapy patients are routinely given liver-protective drugs to reduce liver injury, and before chemotherapy, and after chemotherapy check Liver function, sometimes it will cause kidney function damage, pay attention to patient’s diuretic and other treatment. Hair loss is less common in chemotherapy for gastrointestinal tumors, but this hair loss is often reversible and can be regenerated after hair loss. Local reactions of chemotherapy phlebitis and local tissue necrosis caused by local chemotherapy drug infiltration can be effectively avoided by deep vein placement, but due to the lack of mastering the technique of deep vein placement or the lack of understanding of local reactions of chemotherapy, local reactions of chemotherapy still occur from time to time, phlebitis is actually the stimulating effect of chemotherapy drug on the flowing blood vessels, which is manifested as redness, swelling and pain of blood vessels. Local necrosis is a serious local adverse reaction to chemotherapy, once it occurs, local cold compresses, local anesthetic drug closure, drug topical, etc., and in serious cases, local debridement, skin grafting and other treatments may be required. In addition, the adverse effects of chemotherapy include cardiotoxicity, bladder toxicity, etc. The known cardiotoxic drug is Adriamycin, so the dosage of Adriamycin is strictly limited, and there are many improved drugs of Adriamycin, and the common drugs for bladder toxicity are cyclophosphamide and isocyclophosphamide, but for intestinal tumors, these drugs are rarely used.