The causes of intolerable pain in different parts of the osteophytes are different, and may be related to factors such as stimulation of surrounding tissues, compression of nerves, and joint strangulation. 1. Stimulation of surrounding tissues: Bone spurs can easily stimulate the surrounding soft tissues, and can also cause local inflammatory reaction, thus causing intolerable pain at the site of hyperplasia. 2. Compression of nerves: Bone growths occurring in the cervical and lumbar spine may compress the nerve roots, resulting in pain at the site of the disease, as well as symptoms of peripheral nerve compression such as radiating pain and numbness in the upper or lower extremities. 3. Joint strangulation: osteomalacia caused by knee meniscus injury combined with articular cartilage damage will lead to sudden knee joint movement disorder, also known as joint strangulation, patients may experience severe pain in the knee joint. Patients with osteophytes who experience intolerable pain should go to the hospital as soon as possible to find out the cause and actively cooperate with the doctor to avoid delaying the condition.