The knot in the throat is uncomfortable and oppressive. Clinically, it is mainly seen in the following diseases: First, pharyngitis, clinically reflux pharyngitis is more common, the patient may be accompanied by hiccups, acid reflux, belching and other gastrointestinal digestive juices reflux into the throat, resulting in chronic irritation of the pharynx, and there may be a knot in the throat abnormal sensation. Second, there is a problem with the thyroid gland, the patient may be thyroid nodules, thyroid adenomas and other diseases caused by the laryngeal knot part of the oppressive sensation. In this case, it is recommended to do ultrasound, as well as thyroid function seven tests, to determine. Third, the patient’s pharynx grows something in the throat, and there are common diseases such as epiglottis cyst, acute epiglottitis, malignant tumor of pharynx, hypopharyngeal carcinoma, laryngeal carcinoma and so on. In this case, it is not difficult to find out the diagnosis clinically by doing electronic laryngoscopy.