Pimples are generally referred to as acne, a chronic inflammatory skin disease of the sebaceous glandular units of hair follicles. Common creams used to treat acne include retinoids, benzoyl peroxide, antibiotics and azelaic acid. 1. Retinoids: are the topical medications of choice for mild to moderate acne, such as retinoic acid creams or gels, adapalene gel, tazarotene, and so on. Topical retinoic acid drugs often appear erythema, flaking, burning sensation and other mild skin irritation, can be gradually disappeared with the use of prolonged time. 2. Benzoyl peroxide: has the effect of killing Propionibacterium acnes, can be used to treat inflammatory acne, a few sensitive skin will appear mild irritation. 3. Antibiotics: Common antibiotic ointments include fusidic acid cream, erythromycin ointment, etc. Generally, it is not recommended to be used alone, and it is recommended to be applied in combination with retinoids or benzoyl peroxide. 4. Azelaic acid: it can reduce the bacterial flora on the skin surface and hair follicles, especially on Propionibacterium acnes with inhibitory effect on different types of acne, and its adverse reaction is local mild erythema and tingling. It should be noted that moderate and severe acne is often treated with combination therapy, which often requires simultaneous oral treatment with tetracycline antibiotics, erythromycin, isotretinoin and other medications, as well as photodynamic therapy and fruit acid therapy physiotherapy when necessary. It is recommended that acne patients seek timely medical treatment, standardized treatment under the guidance of a doctor, and avoid private medication to avoid delaying the condition.