Large pimples with redness and hardness are considered to be caused by acne, folliculitis, boils and other diseases. If you want to get rid of them, you can follow the doctor’s instructions and use general treatment and medication according to the different causes. 1. Acne: If acne induces the symptoms of large pimples, patients should do a good job of skin hygiene and care of the affected area, you can use topical retinoic acid cream, adapalene gel and other retinoic acid drugs, to play an anti-inflammatory effect, and you can use benzoyl peroxide and other medications to combat bacteria. 2. Folliculitis: If the symptoms of large acne are induced by folliculitis, patients can use mupirocin ointment, fusidic acid ointment antibiotic drugs, to play anti-inflammatory and anti-infection effect. 3. Boil: If the affected area is swollen and hard because of boils, patients generally do not need treatment and can heal on their own. Early without pus, you can follow the doctor’s instructions to use 20% ichthyol ointment and other antiseptic drugs to achieve anti-inflammatory effect. Patients with large pimples, swelling and hard lumps on the surface of the body are recommended to go to the hospital for treatment according to the cause of the disease.