As a cardiovascular doctor, we not only deal with medication decisively in the face of acute and dangerous cardiovascular diseases, but we are more important to provide health education for our vast number of middle-aged and elderly people with stable coronary artery disease. As the most commonly used cardiovascular drug, aspirin enteric soluble tablets should be given to patients to explain how to take them. Whether this is to be taken early in the morning or at night is a matter of academic debate, and so far there are no results, so we will leave it aside for now. Let’s just say whether it is taken before or after a meal. According to the design principle of the drug, we suggest that enterosoluble aspirin should be taken on an empty stomach before a meal (30 minutes), while ordinary aspirin tablets should be taken half an hour after a meal to reduce the irritation in the stomach. Aspirin for cardiovascular disease is now available in generic enteric tablets. The special feature of enteric tablets is that there is a film on the surface of the aspirin tablets, which we call enteric coating. The enteric coating of enteric aspirin has special chemical properties that can resist the strong gastric acid erosion in the stomach and is not disintegrated in a strong acid environment. Our common sense tells us that the stomach environment is strongly acidic when fasting, with a pH of about 1 to 2, while in the intestine, the internal environment is alkaline. physiology tells us that the pH of the small intestine is about 7.6, and the pH of the large intestine is about 8.3 to 8.4. so the enteric coating of aspirin enteric tablets has a precise enterolytic property that causes the tablets to go to the small intestine before they disintegrate. At this time, the active ingredient of aspirin is released to exert its antithrombotic effect. To reduce stomach irritation. So, can aspirin irritate the intestine? Does it increase the risk of intestinal bleeding? The answer is yes. Then why do we still use aspirin enteric tablets? After reviewing the relevant literature, the main site of action of aspirin side effects is the gastric mucosa, and aspirin can directly stimulate the gastric mucosa, which has less effect on the intestine in comparison. However, for patients with active intestinal bleeding aspirin should be used with caution and must be taken under the guidance of a medical professional.