Both glibenclamide and glimepiride belong to the sulfonylurea class of hypoglycemic agents, and both are insulin-promoting agents. The differences between the two are peak time, half-life, dose range, usage, and side effects, etc., as follows: First, peak time, half-life, dose range, etc.: The peak time of glibenclamide is 2-3 hours, while that of glibenclamide is 1-4 hours. The half-life of glimepiride is 5-8 hours, and that of glibenclamide is 10 hours. The dose range of glimepiride is 1-8 mg/d and glibenclamide is 1.25-15 mg/d, and the two drugs are used differently. Secondly, use in renal insufficiency: Since both glibenclamide itself and its metabolites have hypoglycemic activity, the use of glibenclamide in type 2 diabetic patients with renal insufficiency is prone to severe hypoglycemic events. Glibenclamide is contraindicated in patients with a glomerular filtration rate <60 mL/min, while glimepiride is contraindicated in patients with a glomerular filtration rate <45 mL/min. Third, glibenclamide is more likely to cause hypoglycemia and the duration of hypoglycemia can be very long. Glimepiride also has hypoglycemic side effects, but it is not as common as glibenclamide which is prone to hypoglycemia and the duration will not be very long.