There are two main possibilities for chest pain after drinking: first, gastric ulcer combined with reflux esophagitis, alcohol can stimulate the gastric mucosa, causing the gastric mucosa to contract and spasm leading to gastric reflux into the esophagus, resulting in burning pain behind the sternum and radiating to both sides of the chest, combined with belching, nausea and other discomfort. Second, coronary heart disease, after drinking a lot of alcohol can cause a reflex increase in heart rate, increased myocardial oxygen demand, if suffering from coronary heart disease will appear the symptoms of myocardial ischemia, manifested as a crushing pain in the anterior chest area and can radiate to the back, the pain can be slightly relieved after sublingual nitroglycerin. The chest pain after drinking should immediately suspend drinking, promptly go to the hospital for gastroscopy or electrocardiogram examination, to clarify the cause of pain and targeted treatment, in life should prohibit smoking, alcohol, light diet, to develop good habits of life and rest.