Cefpodoxime and Cefaclor are different in pharmacological effects, clinical applications, adverse reactions and other aspects. 1. Pharmacological effects: cefpodoxime ester is a third-generation cephalosporin, cefaclor is a second-generation cephalosporin. Cefpodoxime ester is not as effective as cefaclor against gram-positive bacteria, but has a stronger effect on gram-negative bacteria and anaerobes. Cefpodoxime is more stable to β-lactamase. 2. Clinical application: Cefaclor can be used for urinary tract infections, biliary tract infections, pneumonia and so on. Cefpodoxime ester is mostly used for pneumonia, severe urinary tract infection, osteomyelitis, meningitis, life-threatening sepsis, etc. 3. Adverse reactions: both may have allergic reactions such as skin rash, urticaria and other adverse reactions such as gastrointestinal reactions. Cefaclor is slightly nephrotoxic, and cefpodoxime is virtually nephrotoxic, but may cause secondary infections such as Candida. Cefpodoxime and Cefaclor are both cephalosporins, prohibited for those who are allergic to cephalosporins, prohibited and other nephrotoxic drugs such as aminoglycoside gentamicin, etc., prohibit alcohol during the drug. It is recommended that the patient consult a doctor in time, according to the condition of the choice of appropriate antibiotic treatment.