Patients with primary biliary cholangitis who are taking anti-inflammatory and cholagogic medications are not recommended to be vaccinated, using the new coronavirus vaccine as an example: Symptoms of primary biliary cholangitis are autoimmune liver disease, mediated by an autoimmune response. If patients with primary biliary cholangitis are taking anti-inflammatory choleretic drugs, vaccination with the new coronavirus vaccine will stimulate protective antibodies in the organism to achieve the effect of immunization, and the double immunization effect will not control the disease and may aggravate it. Primary biliary cholangitis can be considered for vaccination with the new coronavirus vaccine if the condition is stable and there are no obvious symptoms. When receiving the new coronavirus vaccine, one should truthfully report one’s physical condition, medical history, and history of allergy to the relevant doctor, and standardize the new coronavirus vaccination under the advice of the relevant doctor to prevent serious consequences. If there is any adverse reaction after vaccination, you should go to the relevant hospital for diagnosis in time to avoid any effect on your body.