Drinking polyethylene glycol 4000 bulk appears resistant to other laxative methods can be used, such as external suppositories, but also can take pro-dynamic drugs, microecological agents and pro-secretory drugs.
1. Enema drugs and suppositories: mainly including glycerin, compound keratine acid ester preparations and other drugs, can play a lubrication, stimulate the intestinal wall, soften the role of feces. It is recommended for temporary use, and should be used with caution in patients with allergies.
2. Pro-dynamic drugs: such as Prucalopride, acting on the intestinal nerve endings, release motor neurotransmitters, antagonize inhibitory neurotransmitters, or directly on the smooth muscle, increase intestinal power, gastrointestinal peristalsis caused by constipation has a better therapeutic effect.
The main adverse reactions are nausea, diarrhea, abdominal pain and headache. If there is still no therapeutic effect after 4 weeks of use, it is necessary to reassess the patient’s condition and consider whether to continue to take the drug.
3. Microecological agents: including probiotics, prebiotics and synbiotics, which can regulate the imbalance of intestinal flora, promote intestinal peristalsis and gastrointestinal motility recovery, and more and more researchers recommend it as a long-term adjunctive medicine for chronic constipation.
4. Pro-secretory drugs: including linaclotide, rubiprostone, etc. These drugs stimulate the patient’s intestinal tract, increase the secretion of intestinal fluid, and then achieve the purpose of defecation. The drug has certain adverse reactions, such as nausea, diarrhea, abdominal distension, abdominal pain and headache and other symptoms.
When constipation occurs, it is important to seek medical attention and have a laxative program developed by a medical professional.