Polyethylene Glycol and Lactulose are both osmotic laxatives and are both safe in comparison. Polyethylene Glycol 4000, the main ingredient of which is Polyethylene Glycol 4000 (a polymer formed by the condensation of ethylene oxide and water), is a white granule or powder that is mainly used for the relief of constipation. Polyethylene Glycol is not absorbed by the intestines after taking, and is retained in the intestines to increase local osmotic pressure, so that water is retained in the feces, which softens the stool and promotes fecal movement and excretion in the intestines. Lactulose is an osmotic laxative for the treatment of constipation and hepatic encephalopathy. It is converted into lactic acid and acetic acid by digestive tract bacteria in the colon, resulting in a decrease in intestinal pH and a decrease in blood ammonia concentration, thus treating hepatic encephalopathy. It can also increase the volume of feces by retaining water and increase intestinal osmolality, thus exerting a diarrheal effect. It should be noted that both Polyethylene Glycol 4000 and Lactulose should be used under medical supervision.