Radiofrequency therapy is a puncture technique, which is well suited and fully utilizes the pain physician’s specialty and modern medical model of minimally invasive treatment. The insulated needle of radiofrequency therapy is percutaneously punctured to reach the target tissue, and the instrument generates electric current to the exposed tip of the needle, which has nerve monitoring and temperature regulation functions to precisely identify and destroy the nerve tissue, and this physical destruction is more scientific, safe and effective than the analgesic therapy of chemical destruction of nerves. In the 1950s, the first radiofrequency instrument was used in neurosurgery for ablative destruction of the trigeminal nerve to relieve the “world’s first pain”, and radiofrequency destruction of the posterior branch of the spinal nerve and the posterior root node of the spinal nerve can effectively relieve limb pain and posterior trunk pain. However, nerve destruction can cause numbness, ankle biting or burning pain, and even movement disorders, and the regeneration of the destroyed nerve will bring back the pain, which brings a lot of troubles to both doctors and patients. Therefore, except for radiofrequency destruction of lumbar sympathetic ganglion or stellate ganglion, which can effectively eliminate the burning pain, hypersensitivity pain and ischemic pain characteristic of pathological neuralgia and improve the blood supply to the focal area, radiofrequency ablation of nerves is only a helpless method to treat the symptoms of severe pain, and both doctors and patients are reluctant to activate it easily, resulting in The low turn-on rate of RF instruments and high medical costs. In 1997, Sluijter reported a pulsed radiofrequency technique for the treatment of neuralgia, in which a cluster of ultra-high frequency currents at temperatures below 42°C do not destroy the nerves, which has attracted much attention. In more than 3 years of research in our department, we found that pulsed radiofrequency was effective in suppressing pain in a rabbit formalin-induced pain model, increasing analgesic substances such as spinal cord posterior horn and posterior root ganglion SP and brain tissue β-endorphin, and inhibiting the long-range response of C-fiber evoked potentials in the dorsal horn of the rat spinal cord. It is suggested that this technique is likely to exert analgesic effects by altering central analgesic substances or transmission structures in the nerve myelin sheath. We have used pulsed radiofrequency as the preferred analgesic method for superficial neuralgia in herpes zoster, trigeminal nerve, posterior branch of cervicolumbar spinal nerve, spinal nerve, greater occipital nerve, linguopharyngeal nerve and stellate ganglion, with an excellent rate of 60-80%, although the analgesic effect of pulsed radiofrequency, which is called “nerve stem acupuncture” by patients, is not as effective as that of heat-damaged nerves. It is true that it avoids the disadvantage of nerve destruction, and the latter also has the problem of nerve regeneration and pain recurrence. Pulsed radiofrequency does not cause new skin numbness or sensation, and patients can be further treated with other rehabilitation methods during the analgesic period, and once the pain returns, nerve pulsed radiofrequency can be administered again or changed to destructive radiofrequency if necessary.