Urinary urgency and painful urination can be caused by urethritis, cystitis, urethral stones and other diseases. Urethritis patients can take amoxicillin capsules for treatment as prescribed by the doctor, and cystitis patients can take minocycline hydrochloride capsules and other drugs for treatment as prescribed by the doctor. 1. Urethritis: usually due to urethral injury, pathogenic microbial infection, foreign bodies and other factors, often manifested in frequent urination, urinary urgency, urinary pain, may be accompanied by urethral discharge, urinary discomfort and other symptoms. Patients can use amoxicillin capsules, desmopressin tablets, cefixime capsules and other drugs for treatment under the guidance of the doctor. 2. Cystitis: It is usually caused by bladder tuberculosis, E. coli infection and other factors. In the clinic, it is often manifested as urinary discomfort, urinary urgency, urinary frequency, urinary pain and other symptoms, which may be accompanied by fever, lumbago and so on. Patients can follow the doctor’s instructions to use azithromycin tablets, minocycline hydrochloride capsules, cefuroxime tablets and other drugs for treatment. 3. Urethral calculi: usually caused by inflammatory infections, urethral stenosis and other factors, there will be frequent urination, urination pain, difficulty and other symptoms, patients can follow the doctor’s instructions to use sodium hydrogen potassium citrate granules and other drugs for treatment. If the symptoms are serious, surgical methods such as urethral episiotomy and lithotripsy can be used for treatment. Urinary urgency and painful urination can also be caused by other factors, which require different treatments. Patients with symptoms of painful urinary urgency should go to regular hospitals for treatment in time to avoid delays and adverse symptoms.