When a patient’s throat feels bitter, there are two main aspects to consider. The first aspect is that the patient drinks less water, has chronic laryngitis, and sometimes may also have gingivitis or stomatitis, so it can cause the patient to feel particularly bitter inside the mouth. The second aspect is that the patient is considered to have digestive system diseases, such as cholecystitis or bile reflux disease. Therefore, once the situation of bitter throat occurs in life, it is best to go to the hospital for detailed examination. If it is simple pharyngitis, the patient can take orally sweet orange Bingmei tablets, golden lotus granules, or blue scutellaria oral liquid to relieve the patient’s discomfort. If the patient is suffering from cholecystitis or bile reflux disease, it is better to go to the general surgery or gastroenterology department for detailed examination and take oral lansoprazole tablets or estramiprazole enteric soft capsule to relieve the patient’s discomfort.