During chemotherapy couples should moderate coitus, coitus feel uncomfortable to stop coitus, coitus should pay attention to hygiene, contraindication is if the side effects of chemotherapy to avoid coitus. 1. moderate coitus: during chemotherapy couples coitus should be appropriate, coitus frequency should not be too high, coitus action should be gentle, to avoid violent action. 2. stop the coitus in time: if the patient feels less energy or other discomfort during the coitus during chemotherapy, he needs to stop the coitus in time, and consult the doctor in time. 3. Genital hygiene: As the resistance of the body decreases during chemotherapy, the genitals need to be cleaned during intercourse to prevent infection. 4. If the side effects of chemotherapy to avoid cohabitation: if the chemotherapy during the general weakness, nausea and vomiting, decreased libido and other adverse reactions serious, to avoid cohabitation. Chemotherapy patients can be appropriate when the body allows cohabitation, but cohabitation needs to be measured. If serious adverse reactions occur during chemotherapy, it is recommended that patients avoid intercourse and seek medical attention promptly.