Methylcobalamin tablets are different from vitamin B12, the main ingredient of methylcobalamin tablets is methylcobalamin, which is an activated form of vitamin B12, while vitamin B12 usually refers to cyanocobalamin, so the two are different.1. Different forms of action: vitamin B12 includes four forms, namely methylcobalamin, adenosylcobalamin, hydroxocobalamin and cyanocobalamin, of which the first two substances can directly participate in a variety of The first two substances can directly participate in a variety of biochemical reactions in the body and are called coenzyme vitamin B12; if the latter two substances want to participate in life activities, they must be transformed into the form of the first two substances in cells before they can play a role, that is to say, vitamin B12 can play a role in the human body only after it is transformed into methylcobalamin in the body; 2. Different effects: compared with vitamin B12, methylcobalamin has good transferability to nerve tissue, can promote nucleic acid- protein-fat metabolism and repair damaged nerve tissues, which is clinically effective for peripheral neuropathy such as nerve disorders caused by diabetes and polyneuritis, especially for numbness, pain and paralysis; 3. Different absorption methods: when vitamin B12 enters the stomach, it needs to combine with internal factors before it can be absorbed into the blood, so when the stomach is in abnormal condition or the stomach is removed, it is easy to lead to vitamin B12 deficiency. Factors such as poor digestive tract function or patients taking certain medications (e.g., diabetic medications) can also hinder the absorption of vitamin B12. Methylcobalamin is a methylation-active preparation of endogenous coenzyme B12, which does not need to go through absorption and metabolism and can be directly utilized by the body. 4. Different clinical applications: The indications for vitamin B12 are megaloblastic anemia and adjuvant treatment of neuritis, while methylcobalamin is used for peripheral neuropathy and megaloblastic anemia caused by vitamin B12 deficiency. However, in the treatment of peripheral neuropathy, methylcobalamin is better than vitamin B12 in terms of clinical efficacy and safety. 5. Different side effects: The common side effects of vitamin B12 are hypokalemia and hyperuricemia, while the common side effects of methylcobalamin tablets are loss of appetite, nausea, vomiting, diarrhea, etc., and occasionally rash.