Typical manifestations of Parkinson’s disease are tremor, myotonia, and bradykinesia, which are similar to the symptoms of Parkinson’s superimposed syndrome, hereditary Parkinson’s syndrome, and essential tremor. 1. Parkinson’s superimposed syndrome: it mainly includes multi-system atrophy, progressive supranuclear palsy, cortical basal ganglia degeneration, dementia with Lewy bodies, etc. (1) Multi-system atrophy: Clinical manifestations include myotonia and bradykinesia without obvious tremor, or may be accompanied by cerebellar damage and autonomic nerve damage. (2) Progressive supranuclear palsy: symmetrical Parkinson’s disease-like manifestations with postural instability and backward tilt, manifested by common upward or downward paralysis of the eyes. (3) Corticobasal ganglia degeneration: postural or motor tremor, myotonia, or cortical sensory deficits, with cognitive deficits in some patients, and dementia in advanced stages. (4) Lewy body dementia: the symptoms of dementia are more serious, and the onset of dementia can be earlier than the Parkinson’s disease-like manifestations. Early visual hallucinations, as well as delusions, and delirium, can be seen in wakefulness and attention changes. 2. Hereditary Parkinson’s syndrome: including Huntington’s disease, hepatomegaly, liver damage, and primary basal ganglia calcification. 3. Primary tremor: It is difficult to distinguish it from Parkinson’s disease patients whose tremor is the main symptom. Primary tremor has an early onset and is inherited in an autosomal dominant manner. It may affect the head, and has no symptoms such as muscle tonus and bradykinesia. If the above symptoms occur, you need to go to the hospital as soon as possible, the doctor according to the specific conditions, to formulate individualized diagnosis and treatment plan, so as not to delay the condition.