Stage II endometrial cancer should be surgically resected and combined with chemotherapy after surgery to improve the prognosis; those who cannot tolerate surgery can consider radiotherapy, endocrine therapy, targeted therapy, immunotherapy and other methods. Surgery combined with radiotherapy is often preferred for stage II endometrial cancer, which can achieve better therapeutic effect, and even most patients can achieve radical cure. Chemotherapy drugs can use platinum+paclitaxel and so on. For older patients who are unable to undergo surgery, radiotherapy is preferred, and endocrine-related drug therapy, such as tamoxifen, etc., can also be chosen, and some patients can also achieve better therapeutic effect. Targeted drugs such as rapamycin and bevacizumab can also be used. Immunologic drugs such as pembrolizumab can also be used for endometrial cancer, and some patients can achieve better therapeutic effect. It is suggested that patients should choose appropriate treatment methods according to their own conditions and take active treatment in order to avoid delaying their conditions.