Itchy skin in patients with cirrhosis is mostly caused by cholestasis, which can be treated with ursodeoxycholic acid, kolestyramine, rifampicin, naloxone and other drugs. 1. Ursodeoxycholic acid: it can improve biliary stasis, which is helpful for relieving itchy skin in cirrhosis patients, and the main side effects include allergy, palpitation, constipation, headache, and so on. 2. Colesevelam: it is the first-line drug for the treatment of itchy skin caused by cholestasis, the main side effects include constipation, abdominal distension, affecting the absorption of other drugs, and other drugs should be taken at least 4 hours apart. 3. Rifampicin: it can be used as a second-line drug for those who are unable to tolerate or fail to tolerate the treatment of colesevelam, the main side effects include hemolytic anemia, drug-induced hepatic damage, renal impairment, etc., and the adverse effects of the drug should be closely monitored in the course of use. 4. Naloxone: can be used as a third-line drug, the drug is an opioid antagonist, side effects include cardiac arrhythmia, blood pressure abnormality, dyspnea, etc., should start from a small dose, slowly adjusted to the optimal dose. In addition, the above drugs should be taken according to the doctor’s instructions, and are contraindicated in patients with allergy to the above drugs, severe hepatic hypoplasia, and complete biliary obstruction, and the use of rifampicin is prohibited in the early stages of pregnancy. If cirrhosis patients have itchy skin, it is recommended to go to the regular hospital in time, under the guidance of the doctor to carry out targeted treatment, not self-medication, so as not to lead to adverse reactions.