Psoriasis is an immune-related chronic recurrent inflammatory skin disease. The aim of treatment is to control the disease, slow down the progression to the whole body, reduce the self-conscious symptoms and skin damage, avoid recurrence as much as possible and improve the patient’s quality of life. Communication with patients and assessment of their condition are important parts of treatment. When the effect of single therapy is not obvious in patients with moderate or severe psoriasis, combined, replacement or sequential therapy should be given. The following therapeutic principles are proposed: ① Formal: emphasize the use of currently accepted therapeutic drugs and methods in dermatological science; ② Safety: all therapeutic methods should ensure the safety of patients as the first priority, and the occurrence of serious adverse reactions should not be neglected in pursuit of recent efficacy; ③ Individualization: when choosing a therapeutic plan, the condition, needs, tolerance, affordability, previous treatment history and adverse reactions of drugs of patients with psoriasis should be comprehensively considered. (3) Individualization: When selecting treatment plans, we should comprehensively consider psoriasis patients’ conditions, needs, tolerance, financial ability, previous treatment history and adverse reactions to drugs, etc., and formulate treatment plans in a comprehensive and reasonable manner. Treatment of different types of psoriasis 1. Psoriasis arthritis (PsA): Treatment drugs include NSAIDs, anti-rheumatic drugs to improve the condition, glucocorticoids and biological agents. ① NSAIDs are suitable for patients with mild active arthritis, but they are not effective for skin lesions and joint destruction; ② Anti-rheumatic drugs have a slow onset of action and do not have obvious analgesic and anti-inflammatory effects, but they can control the deterioration of the disease and delay the destruction of joint tissues, and are mostly used for moderate to severe cases; ③ Biological agents have good clinical efficacy and can prevent the development of PsA imaging; ④ Reglan has a dual effect of anti-inflammatory and pain relief and immunosuppression It is effective in relieving joint swelling and pain; ⑤ The total glycoside of peony can reduce the symptoms of arthritis. 2. Pustular psoriasis: ①Limited pustular psoriasis: whether palmoplantar pustulosis or continuous acrodermatitis, topical drug therapy is preferred, and the first-line drugs include potent glucocorticoids, vitamin D3 derivatives and vitamin A acid drugs. They should be used alone, in combination or in a sequential fashion. Intractable or frequently recurring cases are treated with NB-UVB or 308 nm excimer light. In severe or recalcitrant cases, systemic therapy is often required, with Ave A preferred. If the effect is unsatisfactory or intolerable, MTX, tretinoin, cyclosporine, morte-macrolide, etc. can be chosen. Ave A, MTX and cyclosporine are the first-line drugs, which can be selected according to the patient’s condition and individual situation. Foreign literature reports that biologic agents are effective in all kinds of pustular psoriasis. 3. Erythrodermic psoriasis: Clean and disinfect rooms and clothing. Use low-irritant or non-irritant protective agents, such as petroleum jelly for external application; 1:8000 potassium permanganate solution or starch bath. Cyclosporine and infliximab have a rapid onset of action in the treatment of erythrodermic psoriasis, while Avelox A and MTX have a slower onset of action and are currently the first-line agents used in the treatment of the disease. Sometimes they can be used in combination.