The sequelae of treating pneumonia with hormones are muscle atrophy and femoral head necrosis. The use of a small amount of hormones for pneumonia in the short term will not cause adverse reactions. If hormones are used in large doses, equivalent to more than twenty milligrams of hydrocortisone, for more than one week continuously in order to pursue short-term efficacy in the treatment of pneumonia, side effects of hormones will occur, such as centripetal obesity, hypertension, hyperglycemia, hyperlipidemia, etc. These side effects will slowly disappear with the discontinuation of hormones. However, some side effects are unrecoverable and serious sequelae appear, such as osteoporosis and muscle atrophy, etc. Especially, the osteoporosis sequelae can cause spontaneous fracture and femoral head necrosis, leading to paralysis and long-term bed rest, which affects the patient’s survival quality. Therefore, when treating pneumonia with hormones, it is important to weigh the pros and cons and use a small amount for a short period of time.