Contraindications to the use of Silegilan include hypersensitivity to the ingredients of Silegilan, and patients with diseases such as active gastric and duodenal ulcers. Silegiran is an antiparkinsonian drug that can be used to treat early Parkinson’s disease or in combination with levodopa and levodopa, as well as peripheral dopa decarboxylase inhibitors. It needs to be contraindicated in people who are allergic to the ingredients in Silegilan, as well as in patients with active gastric and duodenal ulcers. It should also be contraindicated if the patient is taking selective 5-hydroxytryptamine reuptake inhibitors, tricyclic depressants, or 5-hydroxytryptamine norepinephrine reuptake inhibitors. Some patients may experience adverse reactions such as insomnia, nausea, hallucinations, headache, cardiac arrhythmia, and dysuria while taking selegiline. Patients should also follow the doctor’s instructions for regular review during the medication period, so as to understand the recovery of the disease. At the same time, it is necessary to ensure sufficient rest time, do not overwork or stay up late for a long time. Patients should strictly follow the doctor’s instructions to take Silegilan, to avoid the adverse consequences caused by self-medication.