Each drug to lower blood pressure has its own side effects, which can be avoided in a number of ways, and some need to replace the drug, as follows: 1, diuretics, indapamide can bring patients with low potassium performance, some patients with general weakness may be hypokalemia, so that patients can also take oral potassium chloride tablets to reduce hypokalemia; 2, beta-blockers, metoprolol for asthma patients may induce or aggravate asthma. Asthma patients are best not to use such drugs, beta-blockers can also slow down the heart rate, if the patient has pathological sinus node syndrome or other slow arrhythmias, also not suitable for the use of metoprolol beta-blockers; 3, angiotensin-converting enzyme inhibitors, captopril, enalapril and other drugs, the most likely to appear dry cough, the patient with a long-term recurrent cough, can not stand to change the next 4, angiotensin II receptor antagonists, like temisartan and other drugs do not have the side effect of dry cough, but can appear hyperkalemia, for people with high blood potassium and renal artery stenosis is not suitable for use; 5, calcium antagonists, nifedipine can appear swelling of the lower limbs is a side effect, some people use drugs after leg swelling, can be replaced or reduce the amount.