Tuberculosis is a chronic wasting, infectious disease, sometimes the clinical symptoms are not typical, but only weight loss as a non-specific manifestation. The amount of weight loss is more common clinically around 10-30 pounds, with 10 pounds of weight loss being the majority. The patient’s weight loss occurs gradually in the absence of other infections, and is also accompanied by symptoms such as cough, coughing, nighttime hot flashes, night sweats and even blood in the sputum. Weight loss will be more pronounced if there is a combination of diabetes mellitus. Because tuberculosis is a wasting disease and diabetes is also a wasting disease, if both of them exist together, the effect on weight will bring a big change, which can reach more than 30 pounds. Therefore, if the weight loss of simple tuberculosis is well controlled, but if the weight loss is caused by the combination of diabetes, it is also necessary to actively control blood sugar and control the activity of Mycobacterium tuberculosis as early as possible to achieve a two-pronged, win-win cooperation.