The patient is advised to consult the neurology department for hand numbness in the night sleep. If the patient is elderly and has risk factors such as hypertension, diabetes mellitus, hyperlipidemia, etc., it is necessary to improve the cranial magnetic resonance examination to rule out the existence of cerebral infarction. If the patient is young, the possibility of cerebral infarction is smaller, and can first do a cranial CT to rule out the diagnosis. It is necessary to improve the blood sugar, blood fat and other tests, improve the cervical spine magnetic resonance, electromyography, etc. to exclude cervical spondylosis, carpal tunnel syndrome, etc.. If the patient is off-side hand numbness, the disease that needs to be considered is acute cerebrovascular disease. For example, cerebral infarction or cerebral hemorrhage, etc., when the lesion involves the fiber bundles that conduct sensation, it will lead to numbness and discomfort of the patient’s contralateral limbs. If the numbness of a single upper limb or a single lower limb, it is necessary to exclude the possibility of peripheral neuropathy, such as cervical spondylosis, lumbar spondylosis. In addition, the patient’s hand numbness if bilateral, symmetrical numbness, also need to consider peripheral neuropathy. For example, the most common is diabetic peripheral neuropathy, patients will have diabetes mellitus, and often poor glycemic control, the numbness appeared in the glove-like, sock-like changes. Therefore, after a patient develops numbness in the hands, it is recommended to visit the hospital to identify the cause.