Cefixime is an oral cephalosporin III antibiotic, which is effective for treating lower respiratory tract infections, intestinal infections or urinary tract infections. If infants and children have indications for its application, it can be used relatively safely, but it still has certain side effects. A common side effect is gastrointestinal reactions, and some children may experience nausea, vomiting, or even diarrhea after taking it, so special attention should be paid. Some children have a history of allergy to penicillin and cephalosporin, and after taking cefixime, they may have rash, cough aggravation and other allergic conditions, once this happens, they should stop using it immediately. If cefixime is used for a longer period of time, especially for children who have diarrhea themselves, they are prone to intestinal flora disorders, leading to secondary infections, which can aggravate diarrhea and other symptoms, so special attention and care should be paid.